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Updated: Jan 11, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

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免疫学分析表明Treg功能障碍与膝关节骨关节炎疼痛之间存在关联

Marie Binvignat1,2,3, Johanna Dubois1, Maria Marco Salvador1

  • 1Immunoregulation, Immunopathology, Immunotherapy I3 Lab, INSERM UMRS-959, Sorbonne Université, Paris, France.

Arthritis & rheumatology (Hoboken, N.J.)
|November 14, 2025
PubMed
概括

调节性T细胞 (Tregs) 可能在骨关节炎 (OA) 患者中功能障碍,导致OA相关的疼痛. 这项研究确定了与OA疼痛严重程度相关的免疫特征,这表明了新的治疗途径.

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Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement04:22

Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement

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Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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