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儿童视网膜神经纤维层厚度:乌拉尔儿童眼睛研究

Mukharram M Bikbov¹, Gyulli M Kazakbaeva¹, Songhomitra Panda-Jonas^2,3,4,5

¹Ufa Eye Research Institute of Bashkir State Medical University, Ufa, Russia.

Investigative ophthalmology & visual science

|November 14, 2025

概括

怀孕期间母亲吸烟和降低出生体重与俄罗斯学龄儿童周状视网膜神经纤维层 (RNFLT) 厚度较薄有关. 更薄的RNFLT也与较差的认知功能和学业表现相关.

科学领域:

眼科医生眼科眼科
公共卫生公共卫生
儿科儿科儿科

背景情况:

周状视网膜神经纤维层厚度 (RNFLT) 是视神经健康的关键指标.
在儿童群体中评估RNFLT对于理解规范价值和识别眼睛疾病的潜在风险因素至关重要.

研究的目的:

在一大批俄罗斯学龄儿童中评估周状视网膜神经纤维层厚度 (RNFLT).
为了确定与RNFLT在这个人群中的变化相关的因素.

主要方法:

乌拉尔儿童眼睛研究 (UCES) 包括来自俄罗斯的4933名儿童 (平均年龄9.7岁).
光学连贯断层扫描 (OCT) 用于测量3111名儿童的RNFLT.
使用Littmann-Bennet方法对轴长度依赖的底部图像放大进行了校正.

主要成果:

平均经过校正的RNFLT为99.9 ± 10.6μm.
较厚的RNFLT与更高的出生体重,更低的孕妇怀孕期间吸烟,更好的学校成绩,更高的认知功能和更长的轴长度有关.
RNFLT因地区而异,在下部和上部最厚,在鼻子和部最薄.

结论:

怀孕期间母亲吸烟和出生体重较低与显著更瘦的RNFLT有关.
较薄的RNFLT与儿童的认知成绩和学业表现较差相关.
RNFLT显示区域差异,并受到轴长的影响.

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