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子-π相互作用介导的基于铜的纳米平台用于协同化学动力学化学疗法,具有增强的抗癌效率

Yinwei Qiu¹, Fangxiao Li², Shuai Zhang¹

¹Shanghai Key Laboratory of Atomic Control and Application of Inorganic 2D Supermaterials, State Key Laboratory of Materials for Advanced Nuclear Energy, Shanghai Applied Radiation Institute, Shanghai University, Shanghai 200444, China.

Langmuir : the ACS journal of surfaces and colloids

|November 14, 2025

概括

这项研究介绍了一种新的纳米平台,通过稳定铜催化剂和提高过氧化水平来增强癌症治疗. 这种协同方法显著提高了超越单个疗法的抗癌疗效.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

化学动力学疗法 (CDT) 通过产生有毒的基激素,在癌症治疗方面表现有前途.
目前的CDT方法由于不稳定的金属催化剂和低细胞内过氧化 (H2O2) 水平而面临限制.

研究的目的:

设计一种能稳定活性金属催化剂并增强细胞内H2O2的纳米平台,以提高CDT的疗效.
通过使用多功能纳米平台,研究结合CDT与化疗的协同效应.

主要方法:

利用阴离子-π 相互作用稳定 Cu+ 在石墨烯氧化物量子点 (GOQD) 表面上进行芬顿式反应.
同时输送多克索鲁比 (DOX) 丰富细胞内H2O2并提供化疗作用.
开发了一种对pH温度有反应的纳米平台 (RMSN-NH2-GOQD@DOX-Cu),用于增强细胞吸收和药物释放.

主要成果:

该纳米平台证明了Cu+的高效稳定,并促进了Cu+介导的芬顿式反应.
同时提供DOX有效地增加了细胞内H2O2水平,增强了CDT.
实验室研究显示,联合抗癌疗效率为71.4%,明显优于单个CDT (21.9%) 和化疗 (37.3%) 治疗.

结论:

-π相互作用工程是稳定药物输送系统中的金属物种的可行策略.
开发的纳米平台通过结合增强的CDT和化疗,为协同的癌症治疗提供了可通用的方法.
这项工作提供了一个有希望的策略,通过合理的纳米平台设计来增强癌症治疗的有效性.

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