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Updated: Jan 11, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

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RAS/BRAF V600E突变对瘤免疫微环境的影响,在不匹配修复缺陷/微卫星不稳定性,结肠直肠癌等情况下

Mohamed E Salem1, Alberto Puccini2, Elizabeth Mauer3

  • 1Levine Cancer Institute, Charlotte, United States.

Clinical cancer research : an official journal of the American Association for Cancer Research
|November 14, 2025
PubMed
概括

在不匹配修复缺陷结直肠癌 (dMMR CRC) 中的RAS突变与瘤免疫性降低有关. 这些瘤在瘤免疫微环境 (TiME) 中表现出较少的炎症和较少的CD8+T细胞.

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Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells06:44

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