环境肠道功能障碍,全身炎症,生长激素和肯尼亚西部婴儿的线性生长:一个前性的观察队列研究
Mary Iwaret Otiti1, James Dodd2, Alloys K'Oloo3
1Kenya Medical Research Institute (KEMRI), Centre for Global Health Research, Kisumu, Kenya; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
肯尼亚婴儿的环境肠道功能障碍与慢性炎症和生长障碍有关. 准肠道透性可能会改善生长结果.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 全球健康 全球健康
背景情况:
- 环境肠道功能障碍 (EED) 与慢性炎症,生长激素抵抗和婴儿生长障碍有关.
- 这些协会在不同的地理环境中有所不同.
研究的目的:
- 确定肯尼亚西部婴儿肠道病理的发病和进展.
- 探索EED生物标志物,全身炎症,生长激素和线性生长之间的关联.
主要方法:
- 在PROSYNK试验的对照组中对婴儿进行前性观察队列研究.
- 对EED,全身炎症,生长激素和婴儿长度的生物标志物在6周,3个月,6个月和12个月时被测量.
- 随着时间的推移,分析了生物标志物,生长激素和线性生长之间的关联.
主要成果:
- 在6周后,32.9%的婴儿表现出肠道炎症,18.3%的婴儿表现出肠道透性增加.
- 慢性系统性炎症在23.6%的婴儿中存在3个月,并且经常持续.
- 6个月后增加的肠透性 (便α1-抗素) 与随后的线性生长减少有关 (长度对年龄z-score).
结论:
- 针对EED的干预措施,特别是增加肠道透性,在幼儿中可以预防或减少慢性全身炎症.
- 改善肠道健康可以促进肯尼亚西部婴儿的生长和发育.
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