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Updated: Jan 11, 2026

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电可以通过调节线粒体动力学来改善缺血性中风后的运动功能.

Zuanfang Li1, Xinru Ji2, Xiuxiu Wang3

  • 1National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; Innovation and Transformation Center, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.

Brain research bulletin
|November 14, 2025
PubMed
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电针 (EA) 疗法通过调节线粒体动力学,增强葡萄糖代谢和促进ATP生产,改善了患有缺血性中风的老鼠的运动功能.

科学领域:

  • 神经科学是一个神经科学.
  • 整合和补充医学是整合和补充医学.
  • 生物化学 生物化学

背景情况:

  • 在老鼠中,中脑动脉封闭 (MCAO) 是缺血性中风的一个模型.
  • 电针 (EA) 在保护MCAO和改善运动功能方面表现有前途.
  • 在MCAO中EA的治疗作用背后的精确机制需要进一步研究.

研究的目的:

  • 为了研究EA在Quchi (LI11) 和Zusanli (ST36) 针点对MCAO大鼠的运动功能的影响.
  • 阐明底层机制,重点关注线粒体动力学,葡萄糖代谢和ATP生产.

主要方法:

  • 建立了MCAO大鼠模型,EA应用于LI11和ST36针点.
  • 使用滑梯步态分析评估运动功能的评估.
  • 评估脑梗塞体积,皮质形态,葡萄糖代谢 (CEST),ATP水平,线粒体形态 (TEM) 和线粒体动力学基因 (Drp1,Fis1,Mfn2,Mfn1,Opa1) 的表达,通过西斑和qPCR.

主要成果:

  • 治疗EA改善了步行动态,减少了脑梗塞的数量和皮质损伤.
  • EA显著缓解了线粒体形态变化和疾病.
  • EA上调调节了Opa1和下调调节了Drp1,改善了线粒体动力学,葡萄糖代谢和ATP生产.
关键词:
电 ?? 疗法是一种电疗法.中脑动脉封闭中脑动脉封闭线粒体动力学的动态运动器功能 运动器功能

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结论:

  • EA调节线粒体动力学以改善葡萄糖代谢功能障碍.
  • 这项EA的规定最终恢复了MCAO大鼠的运动功能.