探索在社会焦虑障碍中依赖频率的大脑活动和认知功能之间的相关性
Junbing He1, Nadire Aximu2, Tokiko Yoshida3
1Research Center for Child Mental Development, Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Suita, Japan.
Brain research bulletin
|November 14, 2025
概括
社会焦虑障碍 (SAD) 的认知功能与后中枢环中的异常大脑活动有关. 减少低频的大脑波动与SAD患者的认知障碍相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 社会焦虑障碍 (SAD) 是常见的,但其神经基础和认知影响尚未完全理解.
- 以前的研究没有将频率依赖的大脑活动与使用rs-fMRI的SAD的认知表现联系起来.
- 这项研究调查了SAD中自发大脑活动和认知功能之间的关系.
研究的目的:
- 为了检查患有SAD患者的大脑活动的频率依赖性变化.
- 用神经心理测试评估SAD患者的认知功能.
- 为了将脑活动异常与SAD的认知表现和临床症状相关联.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 用于收集27名SAD患者和40名健康对照者的数据.
- 低频波动 (fALFF) 分数幅度的频率依赖性变化在典型,慢-5和慢-4频段中进行了分析.
- 用剑桥神经心理测试自动化电池评估认知功能,并分析相关性.
主要成果:
- 与HC相比,患有SAD的患者在典型和缓慢-5频段的双边后中心回环中表现出较低的平均fALFF (mfALFF),在缓慢-4频段的左侧后中心回环中表现出较低的平均fALFF (mfALFF).
- 在mfALFF和临床症状的严重程度之间没有发现显著的关联.
- 在SAD患者中,mfALFF和认知功能之间发现了显著的相关性.
结论:
- 在SAD中,认知缺陷与自发大脑活动的频率依赖性异常有关,特别是在后中枢环中减少的mFALFF.
- 频率依赖的神经标志物,如后中环中的神经标志物,可能有助于识别和治疗SAD中的认知功能障碍.
- 中枢后活动的异常可能是SAD背后的神经机制的一个关键因素.
更多相关视频
10:45Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions
Published on: July 6, 2011
12.1K
09:14Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
885
相关概念视频
01:28Social Anxiety Disorder
421
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
421
01:19Autism Spectrum Disorder
931
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
931
01:30Generalized Anxiety Disorder
615
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
615
01:18Anxiety: Overview
879
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
879
01:15Causes of Social Behavior II: Cognitive Processes
185
Cognitive processes affect social behavior by guiding how individuals perceive, interpret, and respond to social stimuli. These mental processes enable individuals to assess others' behaviors, attribute causes to their actions, and form expectations based on past experiences.Causes of Behavior and Social JudgmentsIndividuals determine the causes of others' behaviors by distinguishing between personal traits and external circumstances. For example, if a friend frequently arrives late, an...
185
01:30Negative and Cognitive Symptoms of Schizophrenia
431
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
431