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分析:肝脏疾病负担和特纳综合征相关因素

Mohamad Jamalinia¹, Fatemeh Zare¹, Alessandro Mantovani^2,3

¹Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Alimentary pharmacology & therapeutics

|November 14, 2025

概括

在特纳综合征 (TS) 中,肝脏疾病很常见,影响超过26%的个体. 与健康女性相比,TS患者患肝病的风险是健康女性的4-6倍,与X染色体异常有关.

科学领域:

遗传学和内分泌学
肝病学肝病学是一种肝病学.
生殖医学生殖医学

背景情况:

在特纳综合征 (TS) 中,肝病 (LD) 的流行,发病率和风险因素尚未得到充分确立.
关于TS个体肝脏疾病的全谱和负担存在不确定性.

研究的目的:

进行元分析以量化特纳综合征患者肝病的整体负担.
为了确定TS的特定风险因素和遗传异常和肝病之间的关联.

主要方法:

在四个电子数据库中进行了全面的搜索,包括2025年6月为止对型确定的TS个体的观察研究.
使用血清肝酶 (RLE) 升高,ICD代码,成像或组织学来确定肝病.
计算了 95% 置信区间 (CI) 的聚合流行率,发病率和赔率比率 (OR).

主要成果:

包括9728名TS个体在内的40项研究显示,RLE,脂肪性LD (SLD) 和晚期纤维化的患病率分别为26.9%,22.3%和12.2%.
与对照人群相比,TS个体的RLE (OR 3.96),SLD (OR 4.03) 和晚期纤维化 (OR 5.74) 的几率明显更高.
像Xq同染色体这样的特定型增加了RLE风险,而马赛克是保护性的;激素替代疗法没有增加风险.

结论:

肝病是特纳综合征常见的并发症,与年龄相匹配的健康女性相比,风险明显增加.
在TS患者中,X染色体异常与肝脏疾病风险增加的关系更为强烈,而不是催眠症.

关键词:

在X染色体异常.心血管脏代谢健康有纤维化的纤维化.型是一种型.肝脏酶肝脏酶肝脏酶与代谢功能障碍相关的脂肪性肝病.雌激素缺乏症雌激素缺乏症雌激素替代疗法是一种雌激素替代疗法.

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