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Updated: Jan 11, 2026

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帕克利塔克塞尔诱导的外周神经病变的药理动力学模型

Yuchen Sun1, Manjunath P Pai1, N Lynn Henry2

  • 1Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.

Clinical and translational science
|November 14, 2025
PubMed
概括

一个新的药理动力学-药理动力学 (PK-PD) 模型准确地预测了帕克利塔塞尔的化疗诱导的周围神经病变 (CIPN). 这种模型可以帮助个性化帕克利塔塞尔剂量,以减少CIPN并改善患者的治疗结果.

关键词:
帕克利塔克塞尔 (paclitaxel) 是一种药物.周围神经病变 (Peripheral Neuropathy) 是一种神经病变.个性化剂量 个性化剂量制药动力学建模 制药动力学建模药物动力学 药物动力学

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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
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