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Updated: Jan 11, 2026

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长期持续使用古塞尔库马布:在意大利的14个皮肤病中心进行了一项为期5年的多中心回顾性研究

Bernardini Nicoletta1, Caldarola Giacomo2, Richetta Antonio Giovanni3

  • 1Dermatology Unit, A. Fiorini Hospital, Sapienza University of Rome - Polo Pontino, Terracina, Italy.

Dermatology practical & conceptual
|November 14, 2025
PubMed
概括

在5年内,古塞尔库马布在中度至重度的斑块性牛皮患者中表现出很高的持续性. 之前使用IL-17抑制剂与较低的药物存活率有关,这突出了其对长期治疗有效性的影响.

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Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
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