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切割与未切割:furin切割如何重塑SARS-CoV-2尖峰的结构格局

Natesan Mani1, Raghavendran Suresh1, Srirupa Chakraborty1,2,3

  • 1Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA.

Protein science : a publication of the Protein Society
|November 14, 2025
PubMed
概括

SARS-CoV-2尖端蛋白 (S) 的furin裂变通过改变蛋白质动态和结构状态来增强受体结合. 了解这种裂变对于有效的疫苗和治疗开发至关重要.

关键词:
在 NTD 动态上.在 RBD 动态上.在SARS-CoV-2中,尖蛋白质是最常见的.动态交叉相关性,主要组件分析 (PCA)素裂解部位 (FCS) 的位置.通过糖甘介导的调制.分子动力学模拟,分子动力学模拟

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