由于自发药物相关的下巴骨硬化而造成的孔
Jung W Nam1,2
1Wonkwang University College of Dentistry, Sanbon Dental Hospital, Department of Oral and Maxillofacial Surgery.
The Journal of craniofacial surgery
|November 14, 2025
概括
这项研究详细介绍了一例罕见的骨质疏松症老年患者的自发 palatal 骨髓缩病例. 病情进展为耳鼻,突出了与抗吸收疗法和糖尿病相关的潜在风险.
科学领域:
- 口腔和牙面部外科手术
- 内分泌学 在内分泌学.
- 老年医学 老年医学
背景情况:
- 与药物相关的骨 (MRONJ) 经常与牙科手术,如拔牙有关.
- 自发的MRONJ病例,特别是在骨突出部位,不太常见,但有记录.
- 骨质疏松症和糖尿病是老年患者的重要并发症.
研究的目的:
- 报告一种罕见的自发 palatal 骨髓缩病例.
- 在这种背景下,研究耳鼻的发展.
- 讨论脆弱患者自发性MRONJ的潜在病因因素.
主要方法:
- 一位老年骨质疏松患者的病例报告.
- 对患者病史的审查,包括抗吸收疗法和糖尿病.
- 关于自发性MRONJ和口鼻囊形成的文献综述.
主要成果:
- 一个自发的 palatal 骨髓损伤病例进展到一个 oro-nasal .
- 没有发现明显的局部创伤或解剖脆弱性.
- 长时间的抗吸收疗法和控制不良的糖尿病被认为是导致因素.
结论:
- 在易受影响的个体中,自发的 palatal 骨质死结可以在没有明显的触发因素的情况下发生.
- 抗吸收疗法和不受控制的糖尿病可能会增加MRONJ的风险.
- 需要进一步的研究来阐明自发性MRONJ的机制.
相关概念视频
01:22Esophageal Perforation-I: Introduction
405
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
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01:28Esophageal Perforation-II: Clinical Manifestations and Management
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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
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