乳酸菌 乳酸菌cillus Paracasei 调节阴道微生态,抑制阴道菌形成 治疗 Candida 阴道炎
Yunxia Li1, Shuxin Zhou1, Duncan James Lessing1
1Department of Microbiology and Synthetic Biology, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Probiotics and antimicrobial proteins
|November 14, 2025
概括
一种新型益生菌Lacticaseibacillus paracasei CPU-Lps0708,有效地对抗阴道疹 (VVC). 这种菌株减少了真菌负担和炎症,为传统治疗提供了有希望的替代方案.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 医学真菌学 医学真菌学
背景情况:
- Vulvovaginal candidiasis (VVC) 是一种常见的感染,其抗性和复发性日益增加.
- 由于耐药性和高复发率,目前的治疗方法面临挑战,需要新的治疗方法.
研究的目的:
- 为了研究Lacticaseibacillus paracasei CPU-Lps0708作为对VVC的益生菌治疗的疗效.
- 评估菌株对Candida albicans毒性因素,宿主免疫反应和阴道微生物群的影响.
主要方法:
- 在试验室中评估了L. paracasei CPU-Lps0708无细胞培养超体 (CFCS) 的抗候群活性.
- 利用小鼠VVC模型来评估该菌株的体内疗效.
- 在Caenorhabditis elegans感染模型中检查了宿主抵抗机制.
- 分析了治疗后阴道微生物群组成的变化.
主要成果:
- L. paracasei CPU-Lps0708 CFCS 抑制了分别40%和35%的和生物膜形成.
- 该菌株在小鼠VVC模型中减少了阴道真菌负担的114倍.
- 证明了双重机制:增强宿主抵抗力和缓解真菌入侵,炎症和上皮损伤.
- 调节了阴道微生物群,增加了Lactobacillus spp. 和减少的埃舍里希亚菌种群.
结论:
- L. paracasei CPU-Lps0708通过直接的抗真菌活性和宿主微环境的调制,显示出对VVC的显著治疗潜力.
- 该菌株能够恢复阴道微生物群平衡并增强宿主免疫力,使其成为有希望的生物治疗候选者.
- 这种益生菌方法为抗击VVC提供了一种新的策略,同时解决病原体毒性和宿主健康问题.
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