使用SEER数据库构建静脉瘤临床预后因素和名录
Yuyu Wei1, Jialong Tian1, Xiaojun Pang1
1Department of Neurosurgery, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, 310000, Zhejiang, China.
Discover oncology
|November 14, 2025
概括
这项研究分析了超过2万名前庭神经瘤 (VS) 患者,确定年龄,性别,种族,瘤大小,手术和放射治疗是影响整体生存 (OS) 的关键因素. 开发的诺米图表有助于预测长期结果,以便更好地为患者提供咨询.
科学领域:
- 神经瘤学神经瘤学
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 静脉神经瘤 (VS) 是一种罕见的瘤,影响神经VIII.
- 了解长期生存趋势和预后因素对于患者管理至关重要.
研究的目的:
- 确定前庭神经瘤 (VS) 患者的长期整体生存 (OS) 景观.
- 为了确定与OS相关的人口和临床因素在一个庞大的基于人口的队列.
主要方法:
- 利用SEER数据库 (2000-2019) 对一个20,235名VS患者的队列.
- 采用单变量和多变量考克斯比例危险模型来确定预后因素.
- 开发并验证了用于预测3年,5年和10年的运行概率的诺姆图.
主要成果:
- 年龄,性别,种族,瘤大小,主要部位手术和放射治疗被确定为OS的独立预后因素.
- 在训练和验证队列中,诺米图表表现出强大的预测能力,具有高的一致性指数和AUC值.
- 诊断年份,化疗和横向性等因素与OS没有显著的关联.
结论:
- 这项研究提供了对超过20,000名VS患者的长期存活情况的全面概述.
- 确定了影响整体生存的关键人口和治疗因素.
- 开发出来的诺姆图表作为患者评估和咨询关于长期结果的有价值的工具.
关键词:
这个名字叫做Nomogram.总体生存率 总体生存率人口研究研究人口研究.预测因素 预测因素在 SEER 数据库中,我们可以看到静脉状神经瘤 (Vestibular schwannoma) 是一个神经状神经瘤.更多相关视频
07:13Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
468
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
616
相关概念视频
Cancer Survival Analysis
624
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
624
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
