在癌症诊断和治疗中的代谢物和代谢物
Minyi Cai1,2, Haiyan Liu2, Chen Shao2
1Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China.
Molecular biomedicine
|November 14, 2025
概括
代谢学揭示了癌症的关键代谢变化,为早期检测和个性化治疗提供了新的途径. 本综述探讨了代谢物作为诊断生物标志物和治疗点,推进精确瘤学.
科学领域:
- 在瘤学瘤学.
- 代谢学 代谢学 代谢学
- 生物化学 生化学
背景情况:
- 癌症是一个主要的全球健康问题,代谢重编程是其发展和进展的关键因素.
- 代谢学已经成为识别癌细胞及其微环境中的代谢变化的强大工具.
研究的目的:
- 为癌症中代谢组和代谢产物提供全面的系统审查.
- 概括代谢物作为诊断/预后生物标志物和治疗策略中的作用.
- 讨论癌症代谢领域的挑战和未来方向.
主要方法:
- 对癌症代谢学现有文献的系统审查.
- 代谢平台和分析过程的分析.
- 关于将特定代谢物与癌症诊断,预后和治疗反应联系起来的研究摘要.
主要成果:
- 代谢学平台适用于癌症患者的各种生物矩阵.
- 特定的代谢物已被确定为重要的诊断和预后生物标志物.
- 目前针对癌症代谢的治疗策略包括已批准的药物和临床试验中的化合物.
结论:
- 代谢物具有个性化精确癌症治疗的巨大潜力.
- 关键的挑战包括代谢学的技术限制和针对癌症代谢的临床障碍.
- 未来的方向包括多学科的方法和生活方式干预措施,以加强癌症管理.
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