孕期孕产妇在父亲暴露于甲状腺素后的妊娠结果:系统性审查和元分析
Nusret Uysal1, Hüseyin Yilmaz2, Mesut Gungor2
1Department of Medical Pharmacology, Marmara University School of Medicine, Istanbul, Turkey.
Birth defects research
|November 14, 2025
概括
在受孕前,父亲对甲状腺素 (MTX) 的暴露不会增加重大先天性形,死胎或早产的风险. 这一系统性审查为使用MTX的男性怀孕的胎儿安全提供了保证.
科学领域:
- 生殖毒理学 生殖毒理学
- 产周医学 产周医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的证据存在关于怀孕的安全性由男性暴露于甲状腺素 (MTX).
- 在受孕前或在受孕时,父亲对MTX的暴露可能对胎儿发育构成风险.
- 评估这些风险对于生殖咨询和管理至关重要.
研究的目的:
- 系统地审查和元分析父亲MTX暴露与不良妊娠结果之间的关联.
- 为了评估父亲MTX暴露后出现重大先天性形,死胎和早产的风险.
- 提供基于证据的指导,用于管理暴露于MTX.男性的怀孕.
主要方法:
- 在PubMed,Web of Science和Reprotox数据库中的系统文献搜索.
- 包括与未暴露的对照组进行的队列和病例控制研究;排除病例报告和综述.
- 对初级结果进行调整的几率比率的元分析;对数据不足进行叙事综合.
主要成果:
- 没有统计学意义上的重大先天性形风险增加 (aOR 1.00;95% CI 0.62-1.61).
- 没有观察到死产 (OR 0.85;95% CI 0.11-6.45) 或早产 (OR 0.95;95% CI 0.59-1.53) 的风险增加.
- 定性审查发现,在病例报告或病例系列中没有出现一致的发育不良模式.
结论:
- 在受孕前或在受孕时,父亲对MTX的暴露与先天性形,死胎或早产风险的增加无关.
- 研究结果表明,在父亲暴露于MTX后,对这些结果的胎儿安全性.
- 为临床医生和患者提供关于父亲MTX暴露和怀孕结果的保证.
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