大麻使用与口腔癌风险之间的关联:对病例控制研究的系统审查和元分析
Suleiman Ibrahim Mohammad1,2, Asokan Vasudevan3,4, Mahmood Jawad5
1Electronic Marketing and Social Media, Economic and Administrative Sciences, Zarqa University, Zarga, Jordan.
Journal of ethnicity in substance abuse
|November 14, 2025
概括
这一元分析表明,大麻使用可能会降低口腔癌的风险. 然而,由于研究的局限性和关于大麻和癌症的相互矛盾的证据,需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 大麻使用与口腔癌风险之间的联系仍在争论中,现有研究显示结果不一致.
- 了解这种关联对于公共卫生指导和癌症预防策略至关重要.
研究的目的:
- 系统地审查和元分析现有的关于大麻消费和口腔癌发病率的病例控制研究.
- 提供有关大麻使用及其与口腔癌风险相关的证据的定量综合.
主要方法:
- 在主要数据库 (Scopus,PubMed,Web of Science,Embase) 进行了全面的文献搜索,遵循PRISMA指南.
- 经过严格的数据提取和质量评估,包括6项包括4,686例口腔癌和10,370例对照病例的病例控制研究.
- 随机效应模型被用于元分析,使用标准统计方法评估异质性和出版偏差.
主要成果:
- 汇总的几率比率表明大麻使用和口腔癌风险之间存在显著的反向关联 (OR = 0.659,95% CI:0.500-0.869).
- 亚组分析没有显示出明确的剂量反应关系,涉及大麻开始的持续时间,性别或年龄.
- 敏感性分析证实了研究结果的可靠性,并且没有发现显著的出版偏差.
结论:
- 这一元分析表明,大麻使用对口腔癌有潜在的保护作用.
- 然而,方法上的局限性,暴露评估中的异质性和最近的相互矛盾的证据需要谨慎的解释.
- 建议进行大规模前性队列研究,使用标准化暴露测量,以得出关于大麻在口腔癌中的作用的最终结论.
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