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完全封闭循环的胰岛素输送与高碳水化合物和高脂肪餐使用并联自由系统
Tom M Wilkinson1, Martin I de Bock1, Renee Meier1
1Department of Paediatrics, University of Otago, Christchurch, New Zealand.
Journal of diabetes science and technology
|November 14, 2025
概括
一个全新的完全闭环 (FCL) 系统在未预告的高脂肪,高碳水化合物食期间有效地管理了1型糖尿病 (T1D). 这种先进的FCL胰岛素输送证明了T1D患者的安全性和改善范围的时间.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 糖尿病 技术 技术
背景情况:
- 1型糖尿病 (T1D) 管理面临挑战,特别是在未预告的高碳水化合物和高脂肪食物中.
- 评估先进的自动化胰岛素输送系统对于改善T1D的血糖控制至关重要.
研究的目的:
- 评估一种全新的全闭环 (FCL) 胰岛素输送系统的有效性和安全性.
- 评估T1D成年人的FCL系统性能,这些成年人未经预告就食用高碳水化合物和高脂肪的食物.
主要方法:
- 十名患有T1D的成年人参与了一项72小时的酒店研究,使用了Tandem Freedom FCL系统.
- 参与者在没有预告的情况下食用高碳水化合物和高脂肪的食物,并接受每日炼挑战.
- 结果与1周的试行期进行了比较,使用标准的控制系统与餐时间的肉囊.
主要成果:
- 在97.3%的时间里,FCL系统是活跃的,没有糖尿病酸或严重的低血糖事件.
- 在FCL使用期间,70-180 mg/dL的中位时间 (TIR) 为61.0%,而在运行期为56.3%.
- 与运行期 (69.6%) 相比,FCL (95.9%) 的过夜TIR显著改善,低时间低于70 mg/dL (0.4%).
结论:
- 坦德姆自由FCL系统在T1D的成年人中证明了安全性和有效性.
- 在具有挑战性的饮食条件下,在没有饮食预告或注射剂的情况下,FCL胰岛素成功控制了血糖控制.
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