血压变化与心力衰竭风险,NT-proBNP升高和高灵敏度热血素升高有关:动脉样硬化多民族研究 (MESA)
Daniel S Nuyujukian1,2, Jin J Zhou1,3, Juraj Koska2
1Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.
American journal of hypertension
|November 14, 2025
概括
血压变化 (BPV) 与心力衰竭 (HF) 的风险增加以及心脏损伤的早期迹象有关. 这些发现表明,BPV可能在HF发育中起作用.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 流行病学 流行病学
背景情况:
- 血压变化 (BPV) 和发生心力衰竭 (HF) 之间的关系尚不清楚.
- 肺炎和心肌损伤的亚临床标志物也需要进一步调查它们与BPV的关联.
研究的目的:
- 调查访问后的BPV与事件HF风险之间的关联.
- 检查BPV与HF和心肌损伤的亚临床标志物之间的联系.
主要方法:
- 使用了动脉样硬化多民族研究 (MESA) 队列 (n=6,814),在基线时没有心血管疾病的个体.
- 从一次访问到一次访问的BPV估计使用从连续血压测量中独立于平均值 (VIM) 的可变性.
- 考克斯模型和关节纵向生存模型评估了与HF的关联,而逻辑回归分析了与N-终端亲B型性尿素 (NT-proBNP) 和高灵敏心脏素-T (hs-cTnT) 的关联.
主要成果:
- 高血压,特别是VIM-SBP,与发生高血压风险的增加显著相关 (HR=1.33).
- 血压高与NT-proBNP水平升高有关 (VIM-SBP OR=1.26;VIM-DBP OR=1.23). 血压高与NT-proBNP水平升高有关 (VIM-SBP OR=1.26;VIM-DBP OR=1.23).
- BPV (VIM-SBP) 也与hs-cTnT水平升高有关 (OR=1.27),表明心肌损伤.
结论:
- 访问到访问的血压变化与发生的心力衰竭有关.
- 血压风险与HF和心肌损伤的亚临床标志物的纵向增加有关.
- 这些发现表明,BPV可能会导致心力衰竭的发展.
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