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Updated: Jan 11, 2026

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
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Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

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FastSCODE:一种加速的SCODE算法,用于在多核处理器上推断基因调节网络.

Rakbin Sung1, Seongmi Woo1, Dongmin Shin1

  • 1Department of Applied Art and Technology, College of Art and Technology, Chung-Ang University, Anseong 17546, Republic of Korea.

Bioinformatics (Oxford, England)
|November 14, 2025
PubMed
概括

FastSCODE从单细胞RNA测序 (scRNA-seq) 数据显著加速基因调控网络的重建. 这种新方法在使用图形处理单元 (GPU) 的大型数据集上提高了计算性能.

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Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq06:24

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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