维生素D受体信号的早期干扰会导致斑马鱼幼虫持续的发育行为缺陷
Morgan Barnes1,2, Derek Burton1, Kurt Marsden1,2,3
1Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.
PloS one
|November 14, 2025
概括
在斑马鱼早期发育中破坏维生素D受体 (VDR) 信号传递会损害感官处理和神经行为结果,长期影响视觉和声学反应.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 内分泌学 在内分泌学.
背景情况:
- 感官处理和行为对于神经系统的功能至关重要.
- 缺陷与神经精神疾病如焦虑症,自闭症 (ASD) 和精神分裂症有关.
- 环境因素可能会影响感官处理障碍.
研究的目的:
- 调查维生素D (1α,25-二氧维生素D3) 受体在发育早期的信号传递中的作用.
- 为了确定中断的VDR信号对感官处理和神经行为健康的影响.
- 探索维生素D在神经发育中的非性作用.
主要方法:
- 使用了条件主导负 (dnVDR) 转基因斑马鱼系.
- 在受精后24-72小时 (hpf) 间的VDR信号中断.
- 在受精后6天和28天使用视觉和声学刺激评估感觉运动行为 (dpf).
主要成果:
- dnVDR诱导导致视觉运动反应发生变化,活动减少和hypolocomotion.
- 声学惊慌响应显示了长延迟C曲线 (LLC) 的特定衰减和对短延迟C曲线 (SLC) 的中等影响.
- 前脉冲抑制 (PPI) 在幼虫中没有受到影响,但在成年人中显著减弱,表明持续的影响.
结论:
- 在关键发育窗口期间维生素D受体信号传递对于适当的感官处理至关重要.
- 破坏VDR信号导致神经元电路发育不可逆转的缺陷.
- 这些发现表明,在涉及感官处理缺陷的条件下,对神经行为健康结果的潜在影响.
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