生物混合纳米机器人诱导乳酸同位素转换,以逆转免疫环境并促进瘤治疗
Yueyue Fan1, Jiamin Ye1, Gaoli Niu1,2
1Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin 300072, China.
Science advances
|November 14, 2025
概括
这项研究介绍了一种智能纳米机器人,该机器人可以将免疫抑制性瘤乳酸盐 (l-LA) 转化为免疫刺激性d-乳酸盐 (d-LA). 这种方法通过重新编程瘤微环境并增强免疫反应,提高了癌症治疗的有效性.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 瘤细胞糖解产生l-乳酸盐 (l-LA),创造一个免疫抑制的瘤微环境,促进癌症干细胞和减少治疗的有效性.
- 现有的降低l-LA的策略面临挑战,因为固体瘤中的物理障碍和资源利用效率低下.
研究的目的:
- 开发一种智能纳米机器人,用于增强瘤向和深度透.
- 通过将免疫抑制性l-LA转化为免疫刺激性d-乳酸盐 (d-LA) 来重新编程瘤免疫微环境.
主要方法:
- 该纳米机器人集成的金纳米粒子, (Pd) 纳米酶,外膜囊泡 (CMVs) 来自 Lactobacillus crispatus.
- Pd纳米酶催化H2O2到O2以深入瘤透,并在酸性条件下产生基 (·OH) 激素以诱导免疫细胞死亡.
- 用乳酸氧化酶进行工程的CMVs将瘤衍生的l-LA转化为d-LA,抵消免疫抑制.
主要成果:
- 在临床前模型中,纳米机器人展示了增强的瘤向和深度透.
- 将l-LA转换为d-LA有效地逆转了免疫抑制性瘤微环境.
- 观察到显著的抗瘤效应,伴随着增强的免疫反应和调节的瘤微生物组.
结论:
- 智能纳米机器人通过重编程瘤微环境,为癌症治疗提供了一种新的策略.
- 这种方法有望克服与l-LA积累相关的治疗耐药性.
- 进一步的研究可能会探索这个纳米机器人在各种癌症类型中的治疗潜力.
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