结合11年语言成绩的遗传和行为预测因素
Loretta Gasparini1, Daisy A Shepherd1, Katherine Lange1
1Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville 3052, VIC, Australia; Department of Paediatrics, The University of Melbourne, Parkville 3052, VIC, Australia.
对幼儿词汇的遗传倾向并没有改善对童年语言结果的预测. 父母报告的措施仍然是早期识别幼儿语言障碍的最有效工具.
科学领域:
- 发育儿科 发育儿科
- 遗传学 是一个遗传学.
- 语音语言病理学 语音语言病理学
背景情况:
- 早期识别语言障碍对于改善幼儿的结果至关重要.
- 之前的研究发现了父母报告的项目,可以高准确地预测11年的语言结果.
- 这项研究调查了早期词汇的遗传倾向是否可以增强预测模型.
研究的目的:
- 为了确定是否包括多基因分数用于幼儿词汇,可以改善11年语言结果的预测.
- 评估将遗传倾向与父母报告的语言措施相结合的预测准确度.
主要方法:
- 利用了来自维多利亚早期语言研究 (ELVS) 和澳大利亚儿童纵向研究 (LSAC) 的数据.
- 提取了幼儿词汇的多基因分数,并分析了父母在2-3岁时报告的语言项目.
- 采用超级学习者组合方法来预测11年的语言成果 (临床语言基础评估-核心语言得分).
主要成果:
- 多基因分数解释了连续语言结果的最小差异 (<1.3%).
- 将多基因分数添加到表型预测器中,在预测语言结果方面产生了适度,不一致的增加 (高达7%).
- 839名ELVS和1441名LSAC参与者的语言结果数据可用.
结论:
- 对于幼儿词汇的多基因分数在与表型数据相结合时,并不能显著提高对后来的语言结果的预测.
- 目前,父母报告的措施和临床观察是预测语言结果最可靠的方法.
- 进一步的研究可能会探索其他遗传因素或不同的发育阶段用于预测建模.
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