在长期的COVID中,大脑雾的预测因素和长期性
Halee Staggs1, Ansgar Furst2, Colleen Mills-Finnerty3
1VA Palo Alto Health Care System, Palo Alto, CA, USA; War Related Illness and Injury Study Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Psychiatry research
|November 14, 2025
概括
长期的COVID脑雾与生物心理社会因素和认知障碍有关. 大多数患者没有康复,这凸显了有效的长期COVID干预措施的必要性.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 长期COVID是COVID-19之后的慢性疾病,经常导致疲劳和脑雾.
- 长期COVID中脑雾的客观定义缺乏,症状持续时间不清楚.
研究的目的:
- 用生物心理社会因素和认知任务来定义长期COVID中的大脑雾.
- 为了调查长期COVID症状的慢性性,并确定大脑雾的预测因素.
主要方法:
- 招募了两波参与者 (N=793在2023年,N=119在2024年) 进行远程问卷和认知任务.
- 开发了分类和回归模型来诊断长期COVID并评估认知投诉.
- 分析了生物心理社会变量,症状集群和认知表现标志物.
主要成果:
- 一个分类模型在长期COVID诊断中实现了73%的准确性,受压力,社会支持和性别的影响.
- 脑雾与表型有关,包括精神和身体健康症状,而不仅仅是睡眠或身体问题.
- 认知标志物包括阅读/打字速度较慢,反应时间缩短,信息处理变化.
- 在随访时,82.4%的参与者没有从长期COVID中缓解.
结论:
- 生物心理社会因素显著预测长期COVID与大脑雾.
- 长期COVID脑雾的特点是特定的认知性能缺陷.
- 大多数长期COVID病例持续存在,这凸显了改善干预措施的迫切需要.
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