产前金属混合物与儿童中的过敏症状之间的关联
Abhishek Pandey1, Shachi Mistry1, Cecilia Alcala1
1Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY, 10029, USA.
The Science of the total environment
|November 14, 2025
概括
产前接触,铜和等金属混合物与儿童过敏鼻炎症状有关. 这项研究强调了在怀孕期间考虑金属混合物对婴儿过敏风险的重要性.
科学领域:
- 环境健康 环境健康
- 儿科过敏 儿科过敏
- 毒理学 毒理学 毒理学
背景情况:
- 以前的研究表明,怀孕期间个体金属暴露可能会增加产后过敏风险.
- 很少有研究研究了金属混合物对儿童过敏结果的综合作用.
- 了解混合金属暴露对于全面的风险评估至关重要.
研究的目的:
- 检查产前接触金属混合物和儿童过敏症状风险之间的关联.
- 确定导致观察到的混合物效应的关键金属.
主要方法:
- 分析了来自 542 个母婴二合体的血液样本在 PROGRESS 出生队列,墨西哥城.
- 在怀孕的第二个和第三个三个月中,量化 (As), (Cd), (Co),铜 (Cu), (Mn), (Ni) 和 (Pb).
- 用问卷评估4-8岁儿童的亚托皮性皮肤炎和过敏性鼻炎症状.
- 将重复持久WQS回归应用于模拟混合物协会,并对共变量进行调整.
主要成果:
- 在怀孕第二季度使用金属混合物和出现过敏性鼻炎症状的风险增加之间发现了显著的关联 (OR=1.16).
- (Mn),铜 (Cu) 和 (Pb) 被确定为第二季度混合物效应的主要贡献者.
- 在第二和第三个季度的当前过敏性鼻炎症状中也观察到关联,Mn,Cu,Pb,As和Ni被确定为关键贡献者.
结论:
- 产前接触金属混合物与儿童过敏症状,特别是过敏性鼻炎的风险增加有关.
- ,铜,,和是这些不良影响的重要贡献者.
- 这些发现强调需要考虑怀孕期间多次金属暴露对儿童健康结果的综合影响.
更多相关视频
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
2.2K
07:13Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
Published on: March 25, 2016
19.5K
相关概念视频
02:06Allergic Reactions
31.9K
Overview
31.9K
01:36Types of Toxins
3.1K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.1K
01:30Attention-Deficit/Hyperactivity Disorder
725
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
725
01:29Asthma-I: Introduction
3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
01:22Development of Immunocompetence
778
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
778
01:27The Periodic Table and Organismal Elements
22.1K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
22.1K