长期暴露于超细颗粒会加速生物衰老,并增加COPD的呼吸系统脆弱性
Yingfeng Gao1, Xin Meng1, Yi Zhang1
1MEEKL-AERM, College of Environmental Sciences and Engineering, Institute of Tibetan Plateau, and Center for Environment and Health, Peking University, Beijing, China.
Journal of hazardous materials
|November 14, 2025
概括
长期暴露于超细颗粒 (UFPs) 加快慢性阻塞性肺病 (COPD) 患者的生物衰老. 快速的生物衰老加剧了UFP引起的肺损伤和呼吸功能受损.
科学领域:
- 环境健康 环境健康
- 肺部病理学 肺部病理学
- 老年学是指老年学的学科.
背景情况:
- 长期暴露于颗粒物物质与慢性慢性肺炎有关.
- 超细颗粒对COPD的具体影响和生物年龄的作用尚不清楚.
研究的目的:
- 调查长期UFP暴露与COPD患者加速生物衰老之间的关联.
- 探索加速生物衰老是否会改变UFP诱导的呼吸效应.
主要方法:
- 在北京对47名COPD患者进行了纵向面板研究.
- 使用土地使用回归计算估计的UFP年暴露量.
- 评估肺功能,呼吸道炎症和生物年龄 (KDM-BA,PhenoAge).
- 分析了使用线性混合效应模型的关联.
主要成果:
- 每次UFP暴露的IQR增加都与KDM-BA和PhenoAge加速的3.0年增加相关.
- 加快的生物衰老与肺功能和体积的减少有关.
- 生物衰老速度较快的个体对与UFP相关的肺损伤的易感性增加.
结论:
- 长期暴露于UFP会加速COPD患者的生物衰老.
- 加快的生物衰老与呼吸功能受损和对UFP影响的敏感性增加有关.
- 生物年龄可能会改变COPD中与空气污染相关的健康风险.
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