在女性从不吸烟者中,肺癌风险高于大型夫妇研究中的男性
Hui Cai1, Xiao-Ou Shu1, Shenghui Wu2
1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Lung cancer (Amsterdam, Netherlands)
|November 14, 2025
概括
在从未吸烟者 (LCNS) 中,女性比男性更容易患上肺癌. 这项对大型夫妇的队列研究发现,妻子的LCNS比丈夫的LCNS更高,特别是当双方都不吸烟时.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 与男性相比,女性在从未吸烟者 (LCNS) 中对肺癌的易感性仍然是一个争论的话题.
- 了解LCNS的性别差异对于有针对性的预防和治疗策略至关重要.
研究的目的:
- 在从不吸烟者中调查肺癌易感性的基于性别的差异.
- 为了确定女性是否比已婚夫妇中的男性更容易受到LCNS的感染.
主要方法:
- 分析了一项对26,339个已婚异性恋夫妇的队列研究.
- 用年龄标准化发病率 (IRR) 和考克斯回归模型 (HR) 来比较性别之间的肺癌风险.
- 分析根据双方伴侣的吸烟状况进行了分层.
主要成果:
- 妻子的整体肺癌发病率明显低于丈夫 (IRR为0.48).
- 然而,在双非吸烟夫妇中,妻子的肺癌发病率 (IRR 1.57) 和风险 (HR 1.54) 较高.
- 在调整吸烟持续时间和强度时,肺癌风险的性别差异减少.
结论:
- 这项研究提供了来自大型夫妇队列的新证据,表明从未吸烟者中女性对肺癌的易感性增加.
- 这些发现强调了将性别视为非吸烟相关肺癌风险的生物因素的重要性.
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