概念和方法上的缺陷削弱了肠道微生物组与自闭症之间的联系的说法
Kevin J Mitchell1, Darren L Dahly2, Dorothy V M Bishop3
1School of Genetics and Microbiology and Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Neuron
|November 14, 2025
概括
肠道的微生物群.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 将肠道微生物组与自闭症谱系障碍 (ASD) 联系在一起的假设在科学和公共话语中获得了吸引力.
- 引用的证据包括人类观察研究,临床前小鼠模型和临床试验.
研究的目的:
- 批判性地评估现有的科学文献,支持肠道微生物组在自闭症中起因作用.
- 确定这个研究领域的概念和方法的局限性.
主要方法:
- 人类观察研究的系统审查和批判性评估.
- 在自闭症小鼠模型中进行的临床前实验分析.
- 对人类临床试验的评估,调查自闭症的微生物干预措施.
主要成果:
- 支持肠道微生物组与自闭症之间的因果关系的文献以显著的概念和方法缺陷为特征.
- 研究设计,数据解释和通用性的局限性破坏了目前的说法.
- 现有证据并不能确定肠道微生物组与自闭症的病因学或病理生理学之间的因果关系.
结论:
- 目前的证据不足以支持肠道微生物组在自闭症中起因作用.
- 需要使用改进的方法进行进一步的严格研究,以最终评估任何潜在的联系.
- 关于因果关系的说法是过早的,并且没有得到现有的科学数据的支持.
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