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干眼疾病中的角膜敏感性:系统性审查

Emanuele Käser¹, Estelle Reymond², Daniela S Nosch³

¹Institute of Optometry, School of Engineering and Environment, University of Applied Sciences and Arts Northwestern Switzerland FHNW, Olten, Switzerland; Department of Biomedical Engineering, University of Basel, Switzerland.

The ocular surface

|November 14, 2025

概括

干眼病 (DED) 是常见的,但其神经变化不清楚. 这次审查发现使用科切-邦内测量的DED患者的角膜敏感性降低,突出了对标准化研究方法的需求.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
角膜研究角膜研究

背景情况:

干眼病 (DED) 是一种普遍存在的全球性疾病,病理生理学尚不清楚.
角质神经在DED中至关重要,需要研究它们的功能和形态变化.
了解角膜神经功能对于推进DED诊断和治疗至关重要.

研究的目的:

在患有干眼病的患者中,系统地审查和调查角膜神经功能变化.
从现有的文献中综合了DED中角膜敏感性改变的发现.

主要方法:

在PubMed,Web of Science和Scopus进行了系统的文献搜索,直到2025年9月10日,遵守PRISMA指南.
包括的研究测量了DED患者和健康对照者的角膜敏感性.
出版物选择和数据分析是由两个研究人员独立进行的.

主要成果:

包括25项研究 (1580名参与者);19项使用科切-博内特审美计,在DED患者中始终显示角膜敏感性降低.
没有发现角膜敏感度和DED严重程度之间的明确相关性,这可能是由于研究异质.
空气喷气审美测量对机械灵敏度产生了不一致的结果,一些研究报告在环境温度下增加灵敏度.

结论:

科切-波内特测量结果表明,在DED.中角膜机械敏感性下降.
空气喷射美观测的不一致的结果表明,不同角膜神经末端的反应各不相同.
标准化的研究设计和可靠的测量方法对于未来对DED角膜敏感性的研究至关重要.

关键词:

角膜美观测仪是角膜的美观测仪.角质神经是角质神经的一个组成部分.角膜敏感性角膜敏感性干眼疾病是干眼的疾病.

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