在视觉处理过程中,经常使用大麻会调节V1与V1的马功能连接
Lauren K Webert1, Nathan M Petro1, Seth D Springer2
1Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA.
NeuroImage
|November 14, 2025
概括
严重使用大麻会通过改变神经活动影响认知功能. 这项研究发现,虽然基本的玛脑波电路保持完整,但大麻使用者的功能连接受到影响,这可能解释了认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
背景情况:
- 大麻的大量使用与认知缺陷有关.
- 大麻会影响内分泌大麻素受体,影响神经网络,对马波段反应至关重要.
- 以前的研究集中在高阶处理上,忽视了基本的马电路完整性.
研究的目的:
- 调查大麻大量使用对基本玛电路完整性和功能连接性的影响.
- 检查常规大麻使用者和非使用者的视觉诱导任务期间视觉皮层中的马波段反应.
主要方法:
- 高密度磁脑电图 (MEG) 用于84名常规大麻使用者和90名人口统计学上匹配的非使用者.
- 参与者接受了用马波段闪频率 (32 40 和 48 Hz) 的视觉诱导任务.
- 时间频率分析和动态功能连接计算以评估神经活动和网络相互作用.
主要成果:
- 在双边初级视觉皮层 (V1) 中观察到强烈的马引入,32 Hz 响应是最强的.
- 右V1活动在不同群体和频率中比左V1活动强.
- 与对照组相比,大麻组在V1和更高阶视觉区域之间显示了32Hz的功能连接性.
结论:
- 在大量使用大麻的人群中,基本的马电路似乎完好无损.
- 强度大麻使用优先影响玛功能连接,特别是在初级和高级视觉区域之间.
- 改变的玛功能连接性可能是与大麻使用相关的观察到的高阶认知缺陷的基础.
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