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综合基因组和功能分析阐明了Litopenaeus vannamei中的Enterococcus faecium LYB的益生菌特性和宿主反应

Dongdong Wang¹, Yijun Liu², Shishuang Wang²

¹The Key Laboratory of Mariculture (Ocean University of China), Ministry of Education, Qingdao, 266003, China; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.

Fish & shellfish immunology

|November 14, 2025

概括

Enterococcus faecium LYB可以增强太平洋白的生长和生存. 这项研究提供了基因组支持的证据,证明其在水产养殖中作为可持续益生菌的使用,减少了对抗生素的依赖.

科学领域:

水产养殖是水产养殖的一种方式.
微生物学微生物学
动物科学动物科学

背景情况:

水产养殖面临疾病和过度使用抗生素的挑战.
需要可持续的益生菌作为替代品.
Enterococcus faecium是有前途的,但它在中的使用需要更多的研究.

研究的目的:

评估Enterococcus faecium LYB作为太平洋白 (Litopenaeus vannamei) 的新型益生菌.
将基因组分析与益生菌有效性和安全性的功能验证相结合.

主要方法:

对E. faecium LYB的基因组分析以确定有益的特征和选毒性基因.
通过对L. vannamei.的食补充试验进行功能验证.
评估的生长,免疫反应 (Imd/Toll,mTOR信号),以及对抗Vibrio parahaemolyticus的生存挑战.

主要成果:

基因组分析揭示了耐压,粘附和免疫调节的特征,没有检测到高风险毒性基因.
饮食中的E. faecium LYB (1.0 × 10^11 CFU/kg) 显著提高了的生长性能.
补充剂调节了关键的免疫信号通路,并增加了对V. parahaemolyticus的存率.

结论:

这项研究为E. faecium LYB在L. vannamei.中的益生菌疗效提供了全面的基因组支持的证据.
它为开发用于类水产养殖的基于Enterococcus的益生菌建立了合理的基础.
这促进了可持续的水产养殖实践,并减少了对抗生素的依赖.

关键词:

疾病耐药性疾病耐药性肠球菌 (Enterococcus faecium) 是一个有毒的菌株.基因组适应基因组适应增长业绩的表现增长业绩的表现利托佩内亚斯 (Litopenaeus vannamei) 是一个水族群.非特异性免疫力非特异性免疫力

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