在SARS-CoV-2中,尖端蛋白质通过破坏星体细胞Cx43介导的隙结间细胞间通信来诱导类似抑郁的行为
Ruo-Lan Yuan1, Sha-Sha Wang2, Pei-Yi Li1
1Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Brain, behavior, and immunity
|November 14, 2025
概括
长期的COVID抑郁症与由于Cx43.3的减少而导致的天体细胞通信障碍 (GJIC) 有关. 恢复Cx43介导的GJIC为这种衰弱状况提供了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 长期COVID是一个全球性的健康问题,抑郁症是主要症状.
- 神经炎症和天体细胞功能障碍与长期COVID抑郁症有关,但机制尚不清楚.
研究的目的:
- 为了调查星细胞连接素43 (Cx43) 和间隙结细胞间通信 (GJIC) 在长期COVID引起的抑郁症中的作用.
- 探索Cx43介导的GJIC作为抑郁症的治疗点.
主要方法:
- 在中部前额皮质 (mPFC) 中,小鼠接受了SARS-CoV-2尖端受体结合域 (RBD),以模拟长期COVID抑郁症.
- 评估了类似抑郁的行为,神经元刺激性和功能连接性.
- 通过分子和细胞测试评估了星细胞Cx43表达,GJIC和神经炎症.
- 使用Cx43淘汰模式和药理干预.
主要成果:
- RBD注射诱导了抑郁行为,降低了神经元刺激能力,并破坏了大脑连接.
- RBD减少了星细胞Cx43表达和GJIC受损,与增加的神经炎症相关.
- Cx43缺乏或GJIC抑制模仿抑郁症;Cx43恢复/ Celecoxib治疗减轻了症状.
结论:
- 星细胞Cx43介导的GJIC对于维持大脑功能和预防长期COVID中的抑郁症至关重要.
- 针对星系细胞Cx43和GJIC,为长期COVID抑郁症提供了一个有希望的治疗途径.
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