微生物组在免疫治疗中的作用:见解和观点
Meilin Ye1, Houyu Ju2, Guoxin Ren2
1Department of Oral Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, 200011, PR China; National Center for Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, PR China; Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China.
肠道微生物组显著影响癌症免疫治疗结果,影响治疗疗效和毒性. 针对微生物组提供了改善抗瘤疗法的潜在策略,尽管临床转化仍然具有挑战性.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 肠道微生物群和宿主免疫系统的相互作用对于癌症免疫疗法至关重要.
- 微生物群落影响免疫检查点抑制剂的疗效和毒性.
- 微生物组调节系统性和瘤局部免疫.
研究的目的:
- 探索肠道微生物在癌症免疫治疗中的作用.
- 了解微生物群影响抗瘤免疫力的机制.
- 审查针对微生物组的策略,以加强癌症治疗.
主要方法:
- 对肠道微生物组和癌症免疫治疗的临床前和临床研究的综述.
- 对影响治疗反应的微生物成分和代谢物的分析.
- 对微生物组调节干预措施的评估.
主要成果:
- 特定的微生物组合与免疫疗法的疗效和不良反应相关.
- 微生物群影响抗原呈现,效应细胞激活和免疫抑制.
- 微生物代谢产物在治疗反应中起着关键作用.
结论:
- 肠道微生物组是癌症免疫治疗中的关键因素.
- 针对微生物组的疗法 (例如益生菌,FMT,饮食) 显示出作为辅助治疗的前景.
- 需要进一步的研究来克服临床应用中的挑战.
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