身体的状态和糖尿病和并发症:的多阶段效应
Xiaoling Liang1, Linyan Li1, Huiling Lu2
1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Nutrition and Food Hygiene and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The Journal of nutrition
|November 14, 2025
概括
(Se) 状态显示与2型糖尿病 (T2D) 有复杂的关系. 虽然高的Se可能会增加T2D风险,但补充剂似乎不有害,充足的Se可能会改善T2D并发症.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2D) 是一个重要的全球健康问题.
- (Se) 在T2D病原和并发症中的作用仍然不完全理解.
- 最近的研究,包括来自中国的研究,需要对Se与T2D的关联进行全面审查.
研究的目的:
- 从实验,观察,门德尔随机化 (MR) 和随机对照试验 (RCT) 中对在T2D及其并发症中的作用进行全面审查和综合证据.
- 讨论当前研究中的复杂,往往矛盾的发现和局限性.
- 探索关于最佳摄入量饮食建议的含义.
主要方法:
- 综合叙事综合和对各种研究类型的元分析.
- 对Se摄入量和蛋白表达的实验数据的审查.
- 对观察,MR和RCT数据的元分析,评估Se状态和T2D发病率和并发症.
主要成果:
- 实验数据表明,超营养性摄入量或异常的蛋白表达可能会促进类似T2D的表型.
- 观察性和MR研究的元分析表明,高Se状态和T2D风险增加之间存在积极的关联.
- 对RCT的元分析没有支持Se补充会增加T2D发病率.
- 越来越多的证据表明,高Se状态可能会改善T2D患者的预后,并减少并发症 (心血管疾病,病,视网膜病,足部).
- Se显示与代谢功能障碍相关的脂肪性肝病有积极的关联,但可能会预防肝纤维化.
结论:
- 和T2D之间的关系是复杂的,高Se状态可能会增加风险,但补充剂不会有害.
- 适当的含量可能有助于治疗T2D并发症和相关肝脏疾病.
- 需要进一步的研究,以确定最佳的摄入范围,以预防T2D和管理其并发症.
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