"改变即将到来"治疗狼性炎:一篇评论
Niraj B Desai1, Casey Gashti2, William L Whittier2
1University Hospitals Cleveland Medical Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
概括
狼性炎 (LN) 的治疗方法正在超越标准护理. 针对B细胞,T细胞和新途径的新疗法为狼性炎患者提供了改善的结果,旨在减少毒性并提高缓解率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,影响多个器官.
- 狼性炎 (LN) 是一种严重的并发症,影响高达60%的SLE患者,需要早期干预以保持功能.
研究的目的:
- 对多发性和膜性狼性炎的现有和新兴疗法进行审查.
- 突出针对LN的潜在免疫病原发生和本病理特征的策略.
- 讨论LN个性化治疗方法的进展.
主要方法:
- 关于狼炎治疗的当前文献的综述.
- 对已知和新型治疗剂的分析.
- 在LN管理中,专注于免疫学和组织病理学目标.
主要成果:
- 对于LN的标准治疗包括含有细胞毒剂或mycophenolate mofetil (MMF) 的葡萄糖皮质类药物.
- 新兴的附加疗法包括针对B细胞 (贝利穆马布,奥比努祖马布) 和T细胞 (沃克洛斯波林) 的药物.
- 针对补充剂和细胞因子的新疗法正在研究中.
结论:
- 个性化治疗策略正在通过向特定疾病机制来改变LN管理.
- 与传统疗法相比,新疗法在改善缓解和减少毒性方面表现有前途.
- 诱导和维持治疗之间的界限正在模糊,需要适应性治疗策略来长期控制疾病并降低复发率.
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