从不同的牙假体中获得的上和下斑块中的微生物概况的比较分析
Hee-Sun Choi1, Eun-Jin Park2, Eun-Kyoung Pang3
1Fellow, Department of Periodontology, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.
The Journal of prosthetic dentistry
|November 14, 2025
概括
牙科修复显著改变口腔微生物多样性,植入物显示较低的多样性和更高的病原性细菌. 材料的选择会影响口腔健康的结果.
科学领域:
- 口腔微生物学 口腔微生物学
- 牙科的生物材料.
- 牙周病学 牙周病学
背景情况:
- 口腔微生物组对于牙周和周围植入物健康至关重要.
- 有限的研究比较了个体内的不同类型的牙修复中的微生物多样性.
- 一致的,特定于材料的微生物概况尚未得到充分确立.
研究的目的:
- 为了比较与同一参与者的天然牙,金冠,石冠和植入物支持的修复相关的supragingival和subgingival微生物多样性和组成.
- 为了确定特定的修复材料是否会在个体之间诱导可复制的微生物特征.
主要方法:
- 30名参与者参加了所有4种修复类型的研究.
- 16S rRNA测序用于分析微生物多样性和上下膜生物膜的组成.
- 统计分析包括α和β多样性,LEfSe,克鲁斯卡尔-瓦利斯和PERMANOVA测试.
主要成果:
- 黄金和金皇冠显示微生物α多样性明显高于天然牙和植入物.
- 植入物支持的修复表现出最小的微生物多样性,其中厌氧类人群如Clostridiales占主导地位.
- 根据恢复类型观察到明显的微生物集群,与每个材料相关的特定细菌种群有关.
结论:
- 修复性材料显著影响口腔微生物组的组成.
- 植入物支持的修复与微生物多样性减少和致病细菌增加有关.
- 修复材料的选择可能会严重影响长期的牙周和周围植入物健康.
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