健康饮料指数与卵巢储备减少的几率在病例控制研究中的关联
Mahdieh Khodarahmi1, Arghavan Balali2, Mahdi Vajdi2
1Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Scientific reports
|November 14, 2025
概括
坚持健康饮料指数 (HBI) 可能与减小卵巢储备 (DOR) 风险的适度降低有关. 需要进一步的研究来证实女性的这种关联.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养科学 营养科学
- 妇女健康 妇女健康
背景情况:
- 卵巢储备 (DOR) 的减少与生育能力的降低和不良生殖结果有关.
- 饮料质量对卵巢储备的影响尚不清楚.
- 健康饮料指数 (HBI) 为评估饮料摄入质量提供了一个新的框架.
研究的目的:
- 调查健康饮料指数 (HBI) 与卵巢储备减少 (DOR) 风险之间的关联.
- 为了探索饮食饮料模式和参加生育诊所的妇女的卵巢储备标记之间的关系.
主要方法:
- 一项涉及370名女性 (120名DOR病例,250名对照) 的病例控制研究,根据年龄和BMI进行了匹配.
- 通过半定量食品频率问卷 (FFQ) 评估的饮食摄入量.
- 卵巢储备标记包括腹膜毛囊数 (AFC) 和抗穆勒激素 (AMH) 水平;用于分析的多变量逻辑回归.
主要成果:
- 未经调整的分析显示,HBI得分和DOR风险 (OR:0.81) 之间没有显著的关联.
- 在对混因素进行调整后,HBI得分的最高三位数与DOR几率降低8%有关 (aOR:0.92;95%CI:0.41-0.96).
- 观察到的关联是温和的,具有边界统计学意义.
结论:
- 对HBI的更强的坚持可能与减少卵巢储备减少的几率相适度相关.
- 这种关联的临床影响是不确定的,因为效果大小小和边界显著性.
- 需要进一步的前性研究和临床试验来验证这些发现并阐明这种关系.
相关概念视频
Oogenesis
68.9K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
68.9K
Odds Ratio
1.5K
The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
1.5K
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Infertility in Females
3.6K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.6K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
392
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
392
Hormonal Control of the Ovarian Cycle
6.4K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
6.4K
