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包括单细胞在内的全身炎症指数为甲状腺癌的鉴定提供了临床意义

Lobna Refaat¹, Marwa S Eissa^2,3, Ghada N Elnaggar¹

¹Clinical pathology department, National cancer institute, Cairo University, Cairo, Egypt.

Scientific reports

|November 14, 2025

概括

像LMR和SIRI这样的炎症指数可以帮助区分甲状腺癌和良性结节. 这些标记物,以及PLR,SII,NLPR和AISI,显示出作为甲状腺癌支持性诊断工具的潜力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物化学生物化学

背景情况:

甲状腺结节很常见,其中一个子集是恶性.
区分良性和恶性甲状腺结节需要准确的诊断工具.
炎症标志物越来越多地被认为是它们在各种癌症中的作用.

研究的目的:

评估几种炎症指数的诊断和预后价值在患有甲状腺结节的患者.
为了比较甲状腺癌患者,良性结节患者和健康对照患者之间的这些指数.
确定这些指数是否可以区分恶性与良性结节,并分层化甲状腺癌的风险.

主要方法:

评估中性粒细胞与淋巴细胞的比率 (NLR),淋巴细胞与单细胞的比率 (LMR),血小板与淋巴细胞的比率 (PLR),衍生NLR (dNLR),全身炎症指数 (SII),中性粒细胞与淋巴细胞和血小板的比率 (NLPR),全身炎症反应指数 (SIRI) 和全身炎症总指数 (AISI).
在150名甲状腺癌 (TC) 患者,75名良性结节患者和70名健康对照患者中比较了这些指数.
利用统计分析来确定显著差异和预测值.

主要成果:

在TC患者和对照者之间观察到PLR,LMR,SII,NLPR,SIRI和AISI的显著差异.
LMR和SIRI有效地区分了恶性与良性甲状腺结节.
在TC患者中,LMR,PLR,SIRI和AISI与高风险分层相关.
在有淋巴结转移的TC患者中,PLR升高.
LMR,SIRI,AISI和FT4是TC的独立风险因素.
对于评估的指数,没有发现对无病存活率的显著影响.

结论:

LMR,SIRI,AISI和FT4是甲状腺癌的独立风险因素.
在区分恶性和良性甲状腺结节方面,LMR和SIRI显示出前景.
LMR,PLR,SII,NLPR,SIRI和AISI可以作为甲状腺癌的支持性诊断标记物.

关键词:

艾西 (AISI) 公司炎症炎症是一种炎症.在LMR中,只有LMR.在NLR中,它是NLR.在PLR PLR中,在这里,SILLO.斯里里斯里里斯里甲状腺癌是什么?甲状腺癌是什么?

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