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Updated: Jan 11, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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光子计数探测器计算机断层扫描与心磁共振成像进行比较,用于自发冠状动脉剖析中心肌细胞外体积量化

Konstantin Klambauer¹, Andrea Biondo¹, Ernst Klotz²

¹Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Scientific reports

|November 14, 2025

概括

具有晚期增强的光子计数检测器CT有效量化心肌细胞外体体积在自发冠状动脉剖析患者. 这种成像技术与SCAD评估的心脏MRI有很好的一致性.

科学领域:

心脏病学心脏病学
放射学放射学是一门学科.
医疗成像医学成像

背景情况:

自发冠状动脉解剖 (SCAD) 是心肌梗塞的原因之一.
心肌细胞外体积 (ECV) 的量化可以评估SCAD相关的损伤.
具有晚期增强 (LIE) 的光子计数探测器计算机断层扫描 (PCD-CT) 为ECV评估提供了潜力.

研究的目的:

在SCAD患者中使用LIE PCD-CT量化心肌心脏ECV.
为了比较由LIE PCD-CT与心磁共振 (CMR) 获得的ECV测量.
评估LIE PCD-CT用于检测SCAD相关心肌变化的诊断性能.

主要方法:

这是一项前性单中心研究,涉及20名SCAD患者接受LIE PCD-CT和13名CMR患者.
全球和病变特异性ECV被使用LIE PCD-CT和CMR量化.
在两个成像模式之间进行了相关性和一致性分析.

主要成果:

通过LIE PCD-CT测量的损伤ECV为45.2%,相对损伤体积和全球ECV_CT (ρ=0.938) 之间有很强的相关性.
全球ECV_CT切线为28.5%,预测相对损伤体积为<5%,准确度高 (AUC=0.956).
全球ECV_CT (28.0%) 和全球ECV_CMR (29.3%) 没有显著差异,表明良好协议.

结论:

LIE PCD-CT是一种可行的方法,用于在SCAD患者中进行定量心肌心电脉检测.
LIE PCD-CT在全球和病变特定的ECV量化方面与CMR表现出良好的一致性.
这种技术可能有助于SCAD的诊断和管理.

关键词:

心脏磁共振成像心脏磁共振成像细胞外体积的细胞外体积.晚期增强剂是为了增加.光子计数探测器计算机断层扫描.自发的冠状动脉剖析.

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