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避免对副甲状腺癌进行过度诊断

Carl Christofer Juhlin^1,2, Ozgur Mete^3,4,5

¹Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. christofer.juhlin@ki.se.

Virchows Archiv : an international journal of pathology

|November 14, 2025

概括

由于模仿侵入性生长,诊断甲状腺癌具有挑战性. 病理学家需要综合评估多个级别和生物标志物,以确保准确性和避免过度诊断.

科学领域:

手术病理学的外科病理学
在瘤学瘤学.
内分泌学在内分泌学.

背景情况:

甲状腺癌的诊断依赖于识别侵入性生长,这是恶性瘤的关键指标.
将侵袭性特征与文物和模仿物区分开来,对于准确的分期至关重要 (例如,pT1与pT2).
模仿包括活检后的变化,粉碎的文物, peliosis,和流离失所的瘤细胞,复杂的诊断.

研究的目的:

审查副甲状腺癌的诊断挑战,专注于侵入性生长标准和模仿.
要突出可能导致偏甲状腺癌过度诊断的陷.
强调对副甲状腺瘤进行综合诊断工作的重要性.

主要方法:

对副甲状腺癌侵袭的组织学标准的审查.
讨论常见的文物和模仿模拟恶性瘤的模拟.
临床,组织学,免疫组织化学和分子特征的整合.

主要成果:

侵袭性生长包括血管侵袭,淋巴,围神经侵袭和直接侵入相邻结构.
纤维化,粉碎和皮利症等人工物可以模仿入侵.
甲状腺内部位置和副甲状腺瘤症带来了额外的诊断复杂性.

结论:

准确的甲状腺癌诊断需要仔细的评估,以区分真正的入侵和文物.
结合多个组织水平和生物标志物的多方面的方法是必不可少的.
对于病理学家来说,意识到潜在的诊断陷对于避免过度诊断至关重要.

关键词:

不典型的副甲状腺瘤过度诊断是一种过度诊断副甲状腺腺瘤副甲状腺腺瘤副甲状腺癌是什么?病理学病理学病理学

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