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Updated: Jan 11, 2026

Cryo-EM and Single-Particle Analysis with Scipion
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Cryo-EM and Single-Particle Analysis with Scipion

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CryoAtom 改进了用于冷-EM 的模型构建.

Baoquan Su1, Kun Huang2, Zhenling Peng3

  • 1MOE Frontiers Science Center for Nonlinear Expectations, Research Center for Mathematics and Interdisciplinary Sciences, Shandong University, Qingdao, China.

Nature structural & molecular biology
|November 14, 2025
PubMed
概括

CryoAtom通过调整AlphaFold2.2.来增强用于冷电子显微镜 (cryo-EM) 地图的原子模型构建. 这种新的方法提高了模型的完整性和准确性,即使在较低的分辨率,加速蛋白质结构的确定.

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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