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胃癌中的神经活性连接体受体相互作用:一个全面的空间单细胞分析

Lirong Chen¹, Xiao Li¹, Shaocong Mo¹

¹Department of Digestive Diseases, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|November 14, 2025

概括

胃癌中的神经活性联结体受体相互作用与患者的治疗结果较差有关. 表达CHRNE的单细胞巨细胞促进瘤血管生成,这表明CHRNE是胃癌的治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

神经活性联体受体相互作用与胃癌的发展有关.
确切的机制仍然不清楚.

研究的目的:

阐明神经活性联结体受体相互作用在胃癌中的作用.
确定关键的基因和参与这些相互作用的细胞参与者.
探索它们的预后意义和治疗潜力.

主要方法:

分析单细胞,空间和批量转录组数据.
在胃癌组织中进行免疫光验证.
预测建模和路径活动评估.

主要成果:

神经活性联体受体相互作用与单细胞巨细胞 (Mono-Macs) 有关.
高通路活性与预后不佳,肌肉积分增加和免疫检查点水平相关.
在Mono-Macs (CHRNE+ Mono-Macs) 中的CHRNE表达通过VEGFA促进瘤血管生成,将其与预后不佳联系起来.

结论:

单细胞巨细胞在胃癌中受到神经活性联体受体相互作用的显著影响.
通过促进血管生成,CHRNE+ Mono-Macs可能会推动瘤的进展.
神经活性联体受体相互作用,特别是CHRNE,代表了胃癌的潜在治疗标.

关键词:

希尔尼 (CHRNE) 希尔尼 (CHRNE) 是一个位于希腊的城市.胃癌胃癌是指胃癌.单机Macs的使用神经活性连接体受体相互作用

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