慢性肝病中四头肌肌间脂肪组织增加与与健康年龄相匹配的对照人群相比,与改变的肌肉转录组有关
J I Quinlan1,2, T Nicholson3,4, C Bell5
1School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. j.quinlan@bham.ac.uk.
GeroScience
|November 14, 2025
概括
肌肉脂肪透 (骨髓炎) 在慢性肝病 (CLD) 患者中较高,无论位置如何. 这种增加的肌肉间脂肪组织 (IMAT) 与肌肉功能的减少和基因表达的改变相关,可能会加剧肌肉损失.
科学领域:
- 肌肉生理学和病理学
- 慢性肝病研究研究 慢性肝病研究
- 肌肉健康的生物标志物
背景情况:
- 肌肉脂肪的透,或骨髓炎,是肌肉健康和疾病的关键指标.
- 它在慢性肝病 (CLD) 中的患病率和机制性影响仍未得到充分探索,特别是在解剖位置方面.
- 在CLD中肌肉间脂肪组织 (IMAT) 沉积模式需要进一步调查.
研究的目的:
- 研究与健康对照组 (HC) 相比,在患有CLD的患者中,解剖位置之间的骨髓炎的差异.
- 探索IMAT沉积,身体组成,肌肉力量和CLD的习惯性活动之间的关系.
- 分析与CLD中不同IMAT水平相关的转录基因变化.
主要方法:
- 磁共振成像 (MRI) 用于量化33名CLD患者和17名HC患者的四头肌和psoas肌肉中的IMAT.
- 评估了身体组成,肌肉力量和身体活动水平.
- 为了分析基因表达,进行了巨大的横向肌肉活检的RNA测序.
主要成果:
- 与HC相比,患有CLD的患者在四头四和psoas中显示出显著更高的IMAT.
- 四肢体IMAT与BMI,体脂和年龄正相关,与CLD患者的肌肉强度和体力活动负相关.
- 不同的基因表达分析显示,高IMAT和低IMAT的CLD组之间存在明显的转录组形状,高IMAT组中缩和促炎途径的丰富.
结论:
- 在CLD患者中,IMAT不论其解剖部位如何都会升高,并且与肌肉功能减弱有关.
- 身体不活动可能会加剧IMAT积累及其对CLD肌肉健康的负面影响.
- 在CLD中改变的IMAT水平似乎改变了肌肉转录组,可能导致肌肉衰竭.
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