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在第一季度应用个性化诺摩图来预测口唇裂和裂

Xiaocen Yang¹, Shu Huang¹, Qihong Li¹

¹Department of Ultrasound, Chenggong Hospital, Xiamen University, Xiamen, China.

BMC pregnancy and childbirth

|November 14, 2025

概括

一个新的名图模型准确地预测胎儿裂口唇和 (CLP) 在第一季度使用部透光,皇冠长度和面部标记. 这种非侵入性工具可以提升早期的CLP检测,以更好地管理.

科学领域:

医疗成像医学成像
胎儿医学胎儿医学
遗传学遗传学是一个

背景情况:

唇裂 (CLP) 是一种常见的先天性异常,对健康和经济产生重大影响.
早期发现CLP对于及时干预和改善结果至关重要.

研究的目的:

开发和验证一个个性化的诺莫格拉姆模型,用于预测胎儿CLP在头三个月.
在预测模型中纳入胎儿部半透明度厚度 (NT),冠长度 (CRL) 和面部形状标记.

主要方法:

一组单子怀孕的队列接受了第一季度 (11-14周) 查.
胎儿NT,CRL,前额面角 (FMFA) 和下面面角 (IFA) 通过超声波测量.
使用特征选择和多变量分析开发了一个名录模型,使用ROC和PR曲线评估性能.

主要成果:

诺莫格拉姆模型的AUC为0.847,显著超过单个标志物 (FMFA,IFA,NT,CRL).
该模型表现出高精度 (0.977) 和特异性 (0.999),具有良好的灵敏度 (0.482).
校准和决策曲线分析证实了该模型的临床实用性和良好的预测一致性.

结论:

与单个标记物相比,集成的诺莫格拉姆模型在第一季度CLP预测方面显示出优越的诊断性能.
这种实用的,非侵入性的工具有助于早期发现CLP,有助于产前管理和家庭咨询.

关键词:

裂口唇和口裂口唇和口裂口口唇和口裂口唇.面部简介面部简介面部简介第一个三个月的孕期.这个名字叫做Nomogram.超声波学超声波学超声波学

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