多发性硬化症的性功能障碍:流行率,风险因素和对生活质量的影响在大型队列研究中
Ozlem Totuk1, Merve Türkkol2, Feyzullah Yadi2
1Hamidiye Faculty of Medicine, Department of Neurology, Sancaktepe Prof. Dr. Ilhan Varank SUAM, University of Health Sciences, Istanbul, Türkiye. totukozlem@gmail.com.
BMC neurology
|November 14, 2025
概括
性功能障碍影响了近70%的多发性硬化症患者,严重影响了他们的生活质量. 抑郁症是主要的预测因素,但大多数人不会为这些问题寻求医疗帮助.
科学领域:
- 神经学 神经学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 精神病学是一个精神病学.
背景情况:
- 性功能障碍 (SD) 是多发性硬化症 (pwMS) 患者常见但未被认可的问题.
- SD显著降低了 pwMS 的生活质量 (QoL).
- 当前的临床实践往往忽视了 pwMS 中 SD 的评估和管理.
研究的目的:
- 为了确定pwMS中SD的流行率.
- 确定与SD相关的风险因素.
- 评估SD对抑郁和生活质量的影响,并探索寻求帮助的行为.
主要方法:
- 一项涉及504名pwMS在第三级MS诊所的横截面研究.
- 使用亚利桑那州性经验量表 (ASEX) 进行SD评估,使用贝克抑郁量表 (BDI) 进行抑郁,使用简单表格-12 (SF-12) 进行QoL.
- 采用统计分析,包括后勤回归来确定SD的独立预测因素.
主要成果:
- 总体而言,SD患病率为69.0% (女性为73.9%,男性为57.6%).
- 在多变量分析中,女性性别和较高的BDI得分独立与SD有关.
- SD与较低的SF-12 QoL得分有关,只有9.8%的受影响患者寻求医疗帮助.
结论:
- SD在pwMS中非常普遍,并显著影响QoL和抑郁症.
- 抑郁症是SD的强有力的独立预测因素.
- 由于寻求帮助率低,常规查和多学科护理对于在pwMS中解决SD至关重要.
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