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在抑制甲状腺癌发展方面,METTL14介导的RAD21 mRNA表观遗传转录组修饰的机制

Yinzhe Ge¹, Chen Qin¹, Mang Xiao²

¹Department of Otolaryngology Head and Neck Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, 3 Qingchun East Road, Shangcheng District, Hangzhou City, 310000, Zhejiang Province, China.

World journal of surgical oncology

|November 14, 2025

概括

甲基转移酶样14 (METTL14) 通过表观遗传修改RAD21mRNA来抑制甲状腺癌 (TC). METTL14降低了RAD21水平,减少了瘤的生长和进展.

科学领域:

分子生物学分子生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
癌症研究癌症研究

背景情况:

甲状腺癌 (TC) 的发展受到表观遗传修饰的影响.
甲基转移酶样14 (METTL14) 在TC病变发生中的作用需要进一步阐明.

研究的目的:

调查METTL14影响RAD21mRNA表观遗传修饰的机制.
确定METTL14在抑制甲状腺癌发展中的作用.

主要方法:

使用TCGA和Starbase数据库进行表达式分析.
雇佣了免疫组织化学,RT-qPCR,西部斑块和MeRIP测定.
评估了细胞增殖,细胞亡,迁移,入侵和体内瘤的形成.

主要成果:

在TC组织和细胞中,METTL14是下调的,而RAD21是上调的.
过度表达METTL14抑制了TC细胞的增殖,迁移和入侵,促进了细胞亡.
通过m6A修饰,METTL14降低了RAD21mRNA的稳定性和表达,在体内抑制了瘤的生长.

结论:

在甲状腺癌中,METTL14充当瘤抑制剂.
METTL14通过调解RAD21的m6A修饰来抑制瘤发生,从而降低其mRNA稳定性.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.在M6A中,它是M6A.在METTL14中,使用的是METTL14 核武器的扩散在RAD21中使用RAD21.甲状腺癌是什么?甲状腺癌是什么?

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