与肥胖相关的多囊卵巢综合征的发病和治疗
Xiaoling Ouyang1, Qi Zhou2,3, Hong Tang1
1Departments of Gynaecology and Obstetrics, The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China.
Journal of ovarian research
|November 14, 2025
概括
肥胖的多囊卵巢综合征 (PCOS) 涉及复杂的分子通路,如自和内质网膜压力. 了解这些机制是开发新治疗PCOS和肥胖症的关键.
科学领域:
- 妇科内分泌学内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 分子病原体的产生.
背景情况:
- 多囊性卵巢综合征 (PCOS) 影响全球5%-18%的生育年龄妇女,其特点是高雄激素血症,无排卵和多囊性卵巢形态.
- 肥胖症在PCOS患者中越来越普遍,通过胰岛素抵抗和炎症加剧生殖和代谢健康问题.
- 肥胖PCOS的确切病原和治疗目标尚不清楚,需要进一步研究潜在的分子机制.
研究的目的:
- 审查最近关于驱动肥胖相关PCOS自的分子机制的研究.
- 探索细胞内膜网膜应激,肠道微生物群和HPO轴中断在肥胖PCOS中的作用.
- 为了确定PCOS和肥胖的潜在治疗策略.
主要方法:
- 对当前科学文献进行叙述性审查.
- 专注于分子机制,包括自和内质网膜压力.
- 分析肥胖,PCOS,肠道微生物群和HPO轴之间的相互作用.
主要成果:
- 肥胖会显著恶化PCOS症状和代谢功能障碍.
- 自,内分泌网膜应激,肠道失生症和HPO轴的改变都与肥胖的PCOS病变有关.
- 这些分子通路为新的治疗干预提供了潜在的目标.
结论:
- 对自和相关途径的进一步机制研究对于理解肥胖PCOS至关重要.
- 针对分子机制为未来的PCOS和肥胖管理临床干预提供了有希望的途径.
- 本综述为推进这种复杂疾病的研究和治疗策略提供了见解.
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