身体成分调解脂肪酸与NAFLD风险之间的关联:一项前性队列研究
Qishan Yang1, Xinming Xu1, Yue Chen1
1Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, 130 Dongan Road, Shanghai, 200032, China.
中部肥胖部分介导脂肪酸 (FA) 和严重非酒精性脂肪肝疾病 (NAFLD) 之间的联系. 针对饮食和中心脂肪的干预措施是NAFLD预防的关键.
科学领域:
- 代谢健康 代谢健康
- 肝脏疾病研究 肝脏疾病研究
- 营养科学 营养科学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的健康问题.
- 了解循环脂肪酸 (FA),身体成分和NAFLD发病率之间的相互作用至关重要.
研究的目的:
- 调查体质组成的调解作用,特别是脂肪分布,在血FA和严重NAFLD之间的关联中.
- 探索FA与代谢相关的脂肪肝疾病 (MAFLD) 和代谢功能障碍相关的脂肪性肝病 (MASLD) 的横截面关联.
主要方法:
- 使用核磁共振光谱学对107,593名英国生物库参与者的血FA进行分析.
- 考克斯回归模型的应用,以确定严重NAFLD发病率的危险比率.
- 调解分析以量化身体成分指数的作用.
- 跨截面MAFLD和MASLD协会的多变量逻辑回归.
主要成果:
- 更高的单不和脂肪酸 (MUFA) 和和脂肪酸 (SFA) 与严重的NAFLD风险增加有关,而多不和脂肪酸 (PUFA) 显示出保护性关联.
- 中部肥胖指数,包括腰围和身体圆度,介于FA-NAFLD关联的19-36%.
- 腿部和手臂脂肪质量指数也显示出显著的,虽然较小的,调解效应 (分别为13-26%和9-21%).
结论:
- 身体组成,特别是中心肥胖症,在血FA和严重NAFLD之间的关系中起着重要的调解作用.
- 为预防NAFLD,建议结合减轻中心脂肪的策略的饮食干预措施.
- 这些发现支持对管理和预防NAFLD的多因素方法.
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