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相关概念视频

Gastrulation01:56

Gastrulation

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Development of the Heart01:27

Development of the Heart

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
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相关实验视频

Updated: Jan 11, 2026

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
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Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5

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GATA4:编排心脏发育及其他方面.

Laura Heuvelmans1, Dylan Mostert1,2, Giulia Spanò1

  • 1Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.

Cardiovascular research
|November 15, 2025
PubMed
概括
此摘要是机器生成的。

GATA4对于心脏发育和适应压力至关重要. 本综述探讨了GATA4如何使用GATA4.

关键词:
心脏发育的心脏发育心脏病是一种心脏病.心脏性转录因子的转录因子在 GATA4 中,GATA4在GATA4的监管机制.

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Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart
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En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
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相关实验视频

Last Updated: Jan 11, 2026

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
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Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5

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Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart
06:51

Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart

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8.8K
En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
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En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

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科学领域:

  • 心血管生物学 心血管生物学
  • 发展生物学 发展生物学
  • 分子心脏病学分子心脏病学

背景情况:

  • 哺乳动物的心脏发育和恒常性取决于转录因子.
  • GATA结合蛋白4 (GATA4) 对于胚胎心脏形成和应激适应至关重要.
  • GATA4的功能由染色质动态,转录/后转录因子和后翻译修饰调节.

研究的目的:

  • 提供GATA4在心脏发育,生理和疾病中的作用的综合概述.
  • 检查监管机制微调 GATA4 功能.
  • 评估GATA4调制策略用于心脏修复和再生.

主要方法:

  • 文献综述综合了关于GATA4.4的当前研究.
  • 分析GATA4的调节网络,包括染色质占用率.
  • 针对GATA的治疗方法的评估4.

主要成果:

  • GATA4是心脏身份和可塑性的中央调节者.
  • GATA4的功能是由复杂的监管网络调节的.
  • GATA4调制具有心脏修复和再生的潜力.

结论:

  • GATA4是整个心脏生命阶段的关键调节者.
  • 了解GATA4的监管网络是其治疗潜力的关键.
  • GATA4生物学对心脏研究和创新有广泛的影响.