美国参与者的内脏脂肪指数和认知功能障碍之间的关联来自NHANES数据:横截面分析
Long He1, Cheng Xing1, Xueying Yang1
1Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China.
Medicine
|November 15, 2025
概括
较高的内脏脂肪指数 (VAI) 与老年人的认知功能较差有关,特别是处理速度. 然而,在调整了社会人口统计学和心脏代谢因素后,这些关联减弱了,这表明这些混因素在很大程度上解释了这种联系.
科学领域:
- 老年学和认知神经科学
- 心血管健康和代谢综合征
背景情况:
- 内脏脂肪指数 (VAI) 是内脏脂肪积累和胰岛素耐药性的标志物.
- 认知能力下降是老年人群的一个重大问题,与代谢健康有潜在的联系.
研究的目的:
- 调查VAI与美国老年人特定领域认知表现之间的横截面关联.
- 要确定社会人口统计学,生活方式或临床因素是否调解或混这种关系.
主要方法:
- 来自NHANES (2011-2014) 的1323名年龄≥60岁的美国成年人的数据分析.
- 使用CERAD单词列表学习,动物流利性测试和数字符号替换测试 (DSST) 评估认知功能.
- 使用了多个线性回归模型,对共变量进行了顺序调整.
主要成果:
- 最初,更高的VAI与处理速度 (DSST),即时回忆和语义流性呈现了反向关联.
- 这些关联在完全调整社会人口统计和临床并发症后变得无意义.
- 敏感性分析表明,心脏代谢并发症,特别是失脂症,有助于观察到的衰减.
结论:
- 老年人VAI和认知功能之间的粗略关联在很大程度上是由社会人口统计学和心脏代谢因素解释的.
- 需要通过直接内脏脂肪成像和机械生物标志物进行进一步的纵向研究,以澄清独立的预测作用.
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